Franz Arnold Ake

Franz Arnold Ake

Postdoctoral research scientist, Department of Pathology, Stanford University

Publications

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SCALPEL publication

Quantification of transcript isoforms at the single-cell level using SCALPEL

Ake, F., Schilling, M., Fernández-Moya, S.M., Jaya Ganesh, A., et al.

Nature Communications, 2025

A computational framework for quantifying transcript isoforms at single-cell resolution, enabling detailed analysis of isoform diversity and regulation in complex biological systems.

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Parkinson's tri-culture model

Astrocytic Ceruloplasmin Deficiency Triggers Iron Toxicity and Neurodegeneration in a LRRK2 Parkinson's Tri-Culture Model

Testa, V., Montero-Muñoz, J., Baruffi, V., Alzeer, M., Mularoni, L., Fernández-Carasa, I., Simmini, G., Comellas-Comaposada, N., Ake, F.A., Richaud, Y., Weissleder, C., Amengual, J., Fabregat, I., Deleidi, M., Plass, M., Pluchino, S., Raya, A., Consiglio, A.

bioRxiv, 2025

Investigation of astrocytic ceruloplasmin deficiency and its role in iron toxicity and neurodegeneration using a LRRK2 Parkinson's disease tri-culture model.

Preprint DOI

Methanol fixation publication

Methanol fixation is the method of choice for droplet-based single-cell transcriptomics of neural cells

Gutiérrez-Franco, A., Ake, F., Hassan, M.N., Cayuela, N.C., Mularoni, L., Plass, M.

Communications Biology, 2023

Systematic comparison of fixation methods for droplet-based single-cell RNA sequencing reveals methanol as the optimal choice for preserving transcriptional profiles in neural cells.

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